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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
DYRK4
All Species:
12.73
Human Site:
S420
Identified Species:
21.54
UniProt:
Q9NR20
Number Species:
13
Phosphosite Substitution
Charge Score:
-0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9NR20
NP_003836.1
520
59608
S420
Q
T
L
R
K
S
N
S
F
F
P
S
E
T
R
Chimpanzee
Pan troglodytes
XP_001158495
520
59654
S420
Q
T
L
R
K
S
N
S
F
F
P
S
E
T
R
Rhesus Macaque
Macaca mulatta
XP_001101112
520
59434
S420
Q
T
L
R
K
S
S
S
F
F
P
S
E
T
R
Dog
Lupus familis
XP_534917
565
65190
R464
R
Y
R
P
Q
T
L
R
K
P
S
L
C
L
P
Cat
Felis silvestris
Mouse
Mus musculus
Q8BI55
632
72542
R531
R
P
K
P
Q
I
L
R
K
P
G
A
S
I
S
Rat
Rattus norvegicus
Q4V8A3
586
65492
P476
R
R
G
K
K
R
G
P
P
G
S
K
D
W
A
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001509988
466
52101
P367
F
F
D
S
E
G
F
P
K
H
I
T
N
H
K
Chicken
Gallus gallus
Q5ZIU3
526
59419
L425
S
R
E
W
G
N
A
L
K
G
C
D
D
P
L
Frog
Xenopus laevis
Q2TAE3
750
84138
T558
Q
Q
F
P
P
G
W
T
V
P
E
A
P
T
Q
Zebra Danio
Brachydanio rerio
XP_693389
634
72240
D528
R
P
L
R
K
E
S
D
N
N
Y
E
F
T
Y
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9V3D5
722
79590
S514
M
S
S
S
S
S
S
S
G
L
N
S
V
S
Q
Honey Bee
Apis mellifera
XP_396369
614
68978
N496
T
I
A
A
S
T
V
N
A
N
T
N
A
N
A
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P51568
400
46206
L301
T
H
D
N
L
E
H
L
A
M
M
E
R
A
L
Baker's Yeast
Sacchar. cerevisiae
P14680
807
91227
L685
I
H
F
L
G
G
V
L
N
L
N
P
L
E
R
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
97.8
89.2
76.9
N.A.
65.3
38.7
N.A.
54.2
43.1
28
48.9
N.A.
37.5
42.3
N.A.
N.A.
Protein Similarity:
100
99
91.5
81.2
N.A.
71.5
53.9
N.A.
66.1
59.7
43.3
61.8
N.A.
50.1
59.1
N.A.
N.A.
P-Site Identity:
100
100
93.3
0
N.A.
0
6.6
N.A.
0
0
13.3
26.6
N.A.
20
0
N.A.
N.A.
P-Site Similarity:
100
100
100
20
N.A.
20
26.6
N.A.
20
13.3
33.3
40
N.A.
46.6
20
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
23.8
22.6
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
42.5
36.3
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
0
6.6
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
6.6
6.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
8
8
0
0
8
0
15
0
0
15
8
8
15
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
8
0
8
0
0
% C
% Asp:
0
0
15
0
0
0
0
8
0
0
0
8
15
0
0
% D
% Glu:
0
0
8
0
8
15
0
0
0
0
8
15
22
8
0
% E
% Phe:
8
8
15
0
0
0
8
0
22
22
0
0
8
0
0
% F
% Gly:
0
0
8
0
15
22
8
0
8
15
8
0
0
0
0
% G
% His:
0
15
0
0
0
0
8
0
0
8
0
0
0
8
0
% H
% Ile:
8
8
0
0
0
8
0
0
0
0
8
0
0
8
0
% I
% Lys:
0
0
8
8
36
0
0
0
29
0
0
8
0
0
8
% K
% Leu:
0
0
29
8
8
0
15
22
0
15
0
8
8
8
15
% L
% Met:
8
0
0
0
0
0
0
0
0
8
8
0
0
0
0
% M
% Asn:
0
0
0
8
0
8
15
8
15
15
15
8
8
8
0
% N
% Pro:
0
15
0
22
8
0
0
15
8
22
22
8
8
8
8
% P
% Gln:
29
8
0
0
15
0
0
0
0
0
0
0
0
0
15
% Q
% Arg:
29
15
8
29
0
8
0
15
0
0
0
0
8
0
29
% R
% Ser:
8
8
8
15
15
29
22
29
0
0
15
29
8
8
8
% S
% Thr:
15
22
0
0
0
15
0
8
0
0
8
8
0
36
0
% T
% Val:
0
0
0
0
0
0
15
0
8
0
0
0
8
0
0
% V
% Trp:
0
0
0
8
0
0
8
0
0
0
0
0
0
8
0
% W
% Tyr:
0
8
0
0
0
0
0
0
0
0
8
0
0
0
8
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _